Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1594-1599

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Pyrazolopyrimidine Derivatives and Their Antibacterial Activity

Address:   S. Singh*, P. K. Sharma, R. Dudhe and N. Kumar
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut NH-58, Bypass Road, Baghpat Crossing, Meerut- 250005, U.P., India.
*Corresponding Author

A novel series of substituted pyrazolopyrimidine derivatives have been synthesized from substituted hydrazine derivatives and ethoxy (methylene)malanonitrile gives an intermediate (5-amino-1- substituted phenyl pyrazole-4-carbonitrile) (1) which on further react with formic acid, acetic acid/HCl and formamide gives series of (1- substituted phenyl)1H pyrazole [3,4-d] pyrimidine-4(5H)-one (2). The synthesized compounds were characterized on the basis of IR, 1H NMR and mass spectral data. Furthermore, these newly synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Compounds PP-6A, PP-2B, PP-3B and PP-5C showed significant antibacterial activity.
Pyrazole, Pyrazolo[3,4-d]pyrimidines, Antibacterial activity, Heterocycles.
S. Singh, P. K. Sharma, R. Dudhe, N. Kumar. Synthesis of Pyrazolopyrimidine Derivatives and Their Antibacterial Activity. Asian J. Research Chem. 4(10): Oct., 2011; Page 1594-1599.
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