Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1621-1624

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Characterization of Hydrazones, Pyrazoles and Pyrazolones from 8-Amino-6-Chloro Coumarine



Address:   Ashok G. Gadre, V.V. Nawathye, D.B. Dalavi, D. J. Upadhyaya, B. R. Thorat* and R. S. Yamgar
Chemistry Research Laboratory, Patkar-Varde College, Goregaon (W), Mumbai 62.
*Corresponding Author
DOI No:

ABSTRACT:
8-Amino-6-chlorocoumarine has been synthesized by multistep synthesis which involves the successive chlorination and nitration of salicylaldehyde. The coumarin was synthesized by using Perkin reaction. The resulting nitro-compound can be reduced to 8-amino-6-chlorocoumarine. This was then diazotized and then coupled with different ß-diketones and ß-ketoesters gives corresponding hydrazones. The hydrazones were cyclized by reacting with hydrazines to get pyrazole and pyrazolone derivatives.
KEYWORDS:
Coumarin, hydrazones, pyrazoles, pyrazolones, hydrazines, β-diketones.
Cite:
Ashok G. Gadre, V.V. Nawathye, D.B. Dalavi, D. J. Upadhyaya, B. R. Thorat, R. S. Yamgar. Synthesis and Characterization of Hydrazones, Pyrazoles and Pyrazolones from 8-Amino-6-Chloro Coumarine. Asian J. Research Chem. 4(10): Oct., 2011; Page 1621-1624.
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