Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1625-1629

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Quantitative Structure Activity Relationship of Some Substituted 2-Aminopyridines and Fused Bicyclic Rings as inhibitors of Nitric Oxide Synthases



Address:   Amol S. Sherikar*
Department of Pharmaceutical Chemistry, Tatyasaheb Kore College of Pharmacy, Warananagar, Tal- Panhala, Dist- Kolhapur, Maharashtra, India. 416 113.
*Corresponding Author
DOI No:

ABSTRACT:
In the present work, QSAR study has been performed to explore physicochemical requirements of some substituted 2-aminopyridines and fused rings as inhibitors of Nitric Oxide Synthases. QSAR study has been carried out for two isoforms of the Nitric Oxide Synthases (eNOS and nNOS). QSAR models were derived by stepwise multiple regression analysis employing the method of least squares. The best QSAR model describing the Nitric Oxide Synthases inhibitory activity of 2- Aminopyridine and fused bicyclic ring system was selected on the basis of statistical significance and predictive ability as gauged by cross-validation procedure and external test-set method. The statistical quality of generated equations was evaluated considering parameters like correlation coefficient (r), standard error of estimation (SEE), Fischer ratio (F). The predictive ability of models was checked by external test set by calculating Q2. The result of present study may be useful for designing more potent aminopyridine analogues as inhibitors of nitric oxide synthases.
KEYWORDS:
Nitric Oxide Synthases, QSAR, 2-Aminopyridines, multiple regression analysis.
Cite:
Amol S. Sherikar. Quantitative Structure Activity Relationship of Some Substituted 2-Aminopyridines and Fused Bicyclic Rings as inhibitors of Nitric Oxide Synthases. Asian J. Research Chem. 4(10): Oct., 2011; Page 1625-1629.
[View HTML]      [View PDF]



Visitor's No. :   119855