Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1515-1519

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Therapeutic Efficiency of Leucas aspera (Lamiaceae) on Lead Acetate Induced Nephrotoxicity and Oxidative Stress in Male Wistar Rat



Address:   M. Padmaja1, B. Praveen1*, B. Raghunath Reddy2 and P. Venu Madhav3
1Dept. of Pharmaceutical Analysis and Quality Assurance, Raghavendra College of Pharmacy, Anantapur, A.P.
2Dept. of Pharmacology, Sri Venkateshwara University, Tirupathi, Andhra Pradesh, India.
3Dept. of Pharmaceutical Analysis and Quality Assurance, Alliance College of Pharmacy, Hyderabad, A.P., India.
*Corresponding Author
DOI No:

ABSTRACT:
Leucas aspera (Lamiaceae) is a herbaceous medicinal plant used to treat inflammation, skin infections etc in India and other Asian countries. Lead acetate, a common contaminate in water causes liver and kidney necrosis in man and animals. The aim of the present study is to investigate the nephroprotective and antioxidant activities of the methanol extract of L. aspera in three dose levels of 50mg/kg, 100mg/kg and 2000 mg/kg respectively on lead acetate induced toxicity in rats and comparing it with the marketed formulation of Silymarin. Biochemical studies show that there is an reduction in the levels of super oxide dismutase, reduced glutathione, catalase and total proteins in Lead acetate induced groups. These values are retrieved significantly by treatment with L. aspera extracts at three different doses. Apart from these, histopathological changes also reveal the protective nature of the L. aspera extract against lead acetate induced necrotic damage of renal tissues. In conclusion, these data suggest that the methanolic extract of L.aspera can prevent renal damage from lead acetate induced nephrotoxicity in rats and it is likely to be mediated through its antioxidant activities.
KEYWORDS:
Lead acetate, nephroprotectivity, antioxidant, Leucas aspera.
Cite:
M. Padmaja, B. Praveen, B. Raghunath Reddy, P. Venu Madhav. Therapeutic Efficiency of Leucas aspera (Lamiaceae) on Lead Acetate Induced Nephrotoxicity and Oxidative Stress in Male Wistar Rat. Asian J. Research Chem. 4(10): Oct., 2011; Page 1515-1519.
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