Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1526-1528

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV-Spectrophotometric Method for Gabapentin in Bulk Drug and Formulation



Address:   Sampada D. Dalvi*, Pramod H. Sakpal and Pramod L. Ingale
Marathwada Mitra Mandal’s College of Pharmacy, Sr.No. 4/17, Sector No. 34, PCNTDA, Off Kalewadi Phata-Pimpri Road, Thergoan (Kalewadi) Pune – 411033
*Corresponding Author
DOI No:

ABSTRACT:
A simple, rapid and sensitive spectrophotometric method has been developed for determination of Gabapentin in bulk drug and its dosage form. The method is based on diazotization and coupling reaction of the drug with ß-naphthal solution to produce an intense red colored complex exhibiting maximum absorbance at 558 nm. The calibration graph is linear over the range of 10- 50µg/ml for the drug with correlation coefficient (n=6) of 0.997. The various parameters affecting the development and stability of color product were carefully studied and optimized. The proposed method was successfully applied to determine the drug in formulation. The result obtained of this method were in good agreement recommended for the quality control and routine analysis where time, cost effectiveness and high specificity of analytical techniques are of great importance.
KEYWORDS:
Gabapentin, UV, β-naphthol, standard curve method, Recovery studies.
Cite:
Sampada D. Dalvi, Pramod H. Sakpal, Pramod L. Ingale. Development and Validation of UV-Spectrophotometric Method for Gabapentin in Bulk Drug and Formulation. Asian J. Research Chem. 4(10): Oct., 2011; Page 1526-1528.
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