Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  10

Year :  2011

Pages :   1529-1535

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, Characterization, DNA Binding and Antimicrobial Activity of Copper (II) Complexes with 4-Aminoantipyrine Schiff Bases



Address:   B. Anupama, M. Sunitha and C. Gyana Kumari*
Department of Chemistry, Osmania University, Hyderabad -500007, India
*Corresponding Author
DOI No:

ABSTRACT:
The Schiff bases namely 5-Me SALAAP, 3-OMe SALAAP, 3-Br, 5-Cl SALAAP have been prepared by reacting 4-amino antipyrine with 5-methyl salicylaldehyde/3-methoxy salicylaldeyde /3-Br, 5-Cl salicylaldehyde. The Cu(II) complexes have been prepared by reacting copper(II) chloride with those of Schiff bases in alcoholic medium .The complexes are non electrolytes in DMSO. These have been characterized by using elemental analysis, IR, UV-VIs, 1H, 13C NMR, Mass spectra, ESR spectra, Magnetic susceptibility, conductance measurements and thermal (TGA and DTA) anaylsis. The complexes were found to have composition ML2.On basis of elemental and spectral studies, six coordinated geometry is assigned for these complexes. The Schiff bases act as tridentate and coordinate through the azomethine nitrogen, carbonyl oxygen and phenolic oxygen respectively. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods. The synthesized ligands and their metal complexes were screened against bacteria. (E.coli and Staphylococcus aureus). The activity data show that the metal complexes are more potent than Schiff bases.
KEYWORDS:
Schiff bases, aminoantipyrine, DNA binding , Cu (II)complexes, microbial activity.
Cite:
B. Anupama, M. Sunitha, C. Gyana Kumari. Synthesis, Characterization, DNA Binding and Antimicrobial Activity of Copper (II) Complexes with 4-Aminoantipyrine Schiff Bases. Asian J. Research Chem. 4(10): Oct., 2011; Page 1529-1535.
[View HTML]      [View PDF]



Visitor's No. :   106341