Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1712-1716

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Ultrasound-promoted Green Synthesis and Pharmacological Screening of Some Novel 4-(3, 5-diaryl substituted)-4,5-dihydro-1H-pyrazol-1-yl ) Benzene Sulfonamide



Address:   Anna Pratima Nikalje*, Pankaj Malhotra and Mangesh Ghodke
Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Dr.Rafiq Zakaria Campus, Rauza Bagh, P.B. No. 33 Aurangabad (M.S.) 431001 INDIA.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, efficient and green procedure has been developed for the synthesis of novel of 4-(3, 5-diarylsubstituted)-4,5-dihydro-1H-pyrazol-1-yl) benzene sulfonamides using ultrasonic irradiation. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times and milder conditions. A mixture of substituted prop-2-en-1-ones, 4-hydrazinylbenzenesulfonamide hydrochloride and hydrazine hydrate in ethanol and acetic acid was irradiated under ultrasound in an open vessel. The synthesized pyrazolines containing benzenesulphonamide group were evaluated for their anti-inflammatory activity using Carrageenan-induced rat hind paw oedema and have shown promising t anti-inflammatory activity.
KEYWORDS:
Green synthesis, Ultrasound, Pyrazolines, sulphonamides, anti-inflamatory activity.
Cite:
Anna Pratima Nikalje, Pankaj Malhotra, Mangesh Ghodke. Ultrasound-promoted Green Synthesis and Pharmacological Screening of Some Novel 4-(3, 5-diaryl substituted)-4,5-dihydro-1H-pyrazol-1-yl ) Benzene Sulfonamide. Asian J. Research Chem. 4(11): Nov., 2011; Page 1712-1716.
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