Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1752-1754

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Determination of Aripiprazole in Bulk Formulation by Visible Spectrophotometric Methods



Address:   S.V.V. Dhanu Radha*, K.M. Ch. Apparao and K. Ramakrishna
Department of Chemistry-Gitam Institute of Technology, Gitam Institute of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, economical, precise and reproducible visible spectrophotmetric methods have been developed for the estimation of aripiprazole in bulk formulation. The developed methods are based on the formation of charge transfer coloured complex of aripiprazole with N-Bromo succinimide and complex with chloramine-T using double distilled water. The complex with N-Bromo succinimide shows absorbance maxima at 520.0 nm and linearity in the concentration range of 1-20 µg/ml. The extracted complex with chloramine-T shows absorbance maxima at 540.0 nm and the linearity in the concentration range of 0.2-0.8 µg/ml. Results of analysis for both the methods were validated statistically and by recovery studies.
KEYWORDS:
Aripiprazole,UV-Visible Spectrophotometry, Ultra Sonicator, Electronic balance, Millipore double distilled water, N-Bromosuccinimide, Chloramine-T, Gallocyanine.
Cite:
S.V.V. Dhanu Radha, K.M. Ch. Apparao, K. Ramakrishna. Determination of Aripiprazole in Bulk Formulation by Visible Spectrophotometric Methods. Asian J. Research Chem. 4(11): Nov., 2011; Page 1752-1754.
[View HTML]      [View PDF]



Visitor's No. :   126925