Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  11

Year :  2011

Pages :   1695-1700

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Prodrug of 2-Acetoxybenzoic Acid with Amino-Acids

Address:   Y. A. Jaliwala1*,Rahul Chaturvedi1,Arvind Rathore1,Amit Pandit2 and P.K. Mohanty1
1VNS Institute of Pharmacy, Bhopal, (MP), India.
2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore
*Corresponding Author

2-Acetoxybenzoic acid suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study was aimed to retard the adverse effects of gastrointestinal origin. 4 prodrugs of 2-Acetoxybenzoic acid were synthesized by amidation with ethyl esters of amino acids, namely, glycine, L-phenylalanine, L-glutamic acid, L-aspartic acid. Puri?ed synthesized prodrugs were characterized by m.p., TLC, solubility, elemental analyses, UV, FTIR, NMR. Synthesized prodrugs were subjected for Antypyretic, Analgesic, Anti-in?ammatory activities and Ulcerogenic index. Marked reduction of ulcerogenic index and comparable Antypyretic, Analgesic, Anti-in?ammatory activities were obtained in all cases as compared to 2-Acetoxybenzoic acid.
Prodrugs, Bioavailability, Physical characterization, Pharmacokinetics, Pharmacodyanamics,
Y. A. Jaliwala,Rahul Chaturvedi, Arvind Rathore, Amit Pandit, P.K. Mohanty. Synthesis and Evaluation of Prodrug of 2-Acetoxybenzoic Acid with Amino-Acids. Asian J. Research Chem. 4(11): Nov., 2011; Page 1695-1700.
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