Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1836-1839

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Method



Address:   Naresh M. Kalsariya*, R.M. Chodavadia, P.B. Patel, Z.N. Mevada, B.P. Marolia and S.A. Shah
Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, Gujarat, India- 394 350
*Corresponding Author
DOI No:

ABSTRACT:
Two spectroscopic methods for simultaneous estimation of cefpodoxime proxetil (CP) and ofloxacin (OFL) in combined tablet dosage form have been developed. The first method is simultaneous equations method which involves the formation of simultaneous equations at 234.90 nm (?max of cefpodoxime) and 298 nm (?max of ofloxacin). The second method is Q-analysis method (Q-absorbance ratio), which involves the formation of Q-absorbance equation at 271.60 nm (Iso-absorptive point) and 298 nm (?max of ofloxacin). In this both method the linearity was evaluated over the concentration range of 2-10µg/ml for cefpodoxime and ofloxacin. The accuracy of the methods were assessed by recovery studies and was found to be 100.9±0.16% and 98.22±0.44% for simultaneous equations method and 99.5±0.133% and 98.90±0.65% for Q-absorbance ratio method for cefpodoxime and ofloxacin respectively. The proposed methods are simple, accurate, precise, rapid and cost effective. Therefore the proposed methods can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.
KEYWORDS:
Q-analysis method, Iso-absorptive point, CP and OFL.
Cite:
Naresh M. Kalsariya, R.M. Chodavadia, P.B. Patel, Z.N. Mevada, B.P. Marolia, S.A. Shah. Simultaneous Estimation of Cefpodoxime Proxetil and Ofloxacin in Combined Dosage Form by UV-Spectrophotometric Method. Asian J. Research Chem. 4(12): Dec., 2011; Page 1836-1839.
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