Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1840-1803

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of New Indoline-2-Ones and Their Microbial Activity



Address:   Freddy H. Havaldar*, Azadkumar S. Sharma and Peter Roni F. Pinto
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001.
*Corresponding Author
DOI No:

ABSTRACT:
The acid hydrazides (I and IV) were condensed with indole-2,3-dione in ethanol to yield hydrazono-indolin-2-ones (II and V) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-hydrazono-indolin-2-ones (IIIa-e and VIa-e). The structures of the newly synthesized compounds have been confirmed by IR, 1H NMR and Mass spectra. These compounds have shown promising biological activity.
KEYWORDS:
Synthesis, Mannich bases, biological activity and spectral data.
Cite:
Freddy H. Havaldar, Azadkumar S. Sharma, Peter Roni F. Pinto. Synthesis of New Indoline-2-Ones and Their Microbial Activity. Asian J. Research Chem. 4(12): Dec., 2011; Page 1840-1803.
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