Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  12

Year :  2011

Pages :   1840-1803

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of New Indoline-2-Ones and Their Microbial Activity

Address:   Freddy H. Havaldar*, Azadkumar S. Sharma and Peter Roni F. Pinto
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001.
*Corresponding Author

The acid hydrazides (I and IV) were condensed with indole-2,3-dione in ethanol to yield hydrazono-indolin-2-ones (II and V) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-hydrazono-indolin-2-ones (IIIa-e and VIa-e). The structures of the newly synthesized compounds have been confirmed by IR, 1H NMR and Mass spectra. These compounds have shown promising biological activity.
Synthesis, Mannich bases, biological activity and spectral data.
Freddy H. Havaldar, Azadkumar S. Sharma, Peter Roni F. Pinto. Synthesis of New Indoline-2-Ones and Their Microbial Activity. Asian J. Research Chem. 4(12): Dec., 2011; Page 1840-1803.
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