Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   167-180

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro



Address:   Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel and Dhrubo Jyoti Sen*
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
The inner eye of chemistry looks forward to the biology for getting the best output to design a potent drug molecule after crossing the iron gates of pharmacological as well as clinical trials. The basic scientific research in pharmacy is blooming in the impact of the compatibility of designed chemical molecule towards biological molecule. Latest technology in pharmaceutical science reflects the implementation of new methodologies to screen a new chemical entity in a biological system. The inner eye of chemistry looks forward to the biology for getting the best output to design a potent drug molecule after crossing the iron gates of pharmacological as well as clinical trials. The basic scientific research in pharmacy is blooming in the impact of the compatibility of designed chemical molecule towards biological molecule. Latest technology in pharmaceutical science reflects the implementation of new methodologies to screen a new chemical entity in a biological system. A representative problem in bioinformatics is the assembly of high-quality genome sequences from fragmentary "shotgun" DNA sequencing. Other common problems include the study of gene to perform expression profiling using data from microarrays or mass spectrometry. Framing the structural framework of a chemical molecule is first done by in-silico by computational chemistry and that is synthesized by in-situ method. This after synthesis the biological screening is done by both in-vitro and in-vivo studies to enlist as a potent moiety by QSAR. All these newer techniques possess a prefix “In” for in-vitro, in-vivo, in-situ and in-silico which are the In-ner eye of the members of pharmaceutical reserch.
KEYWORDS:
Optimization, Molecular Dynamics, Monte Carlo, Replica exchange method, Quantum mechanics, in-vitro, in-vivo, in-situ, in-papyro and in-silico.
Cite:
Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen. Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro. Asian J. Research Chem. 4(2): February 2011; Page 167-180.
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