Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   221-226

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis of Some New 5-(4-(Phenylamino) Phenyl)-1, 3, 4-Thiadiazol-2-Amine Derivatives as Potent Antifungal Agents.



Address:   Anoop Singh1* and A.C. Rana2
1Department of Pharmaceutical Chemistry, Bhupal Nobles College of Pharmacy, Udaipur (Rajasthan), India-313001
2Rayat Institute of Pharmacy, Rail Majra, Ropar (Punjab)- India
*Corresponding Author
DOI No:

ABSTRACT:
Recently a series of 5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-amine derivatives were synthesized and their pharmacologically evaluated for antifungal activity. The purpose of this study was to evaluate the effects of the title compounds on fungal activity by varying the substituted in the1,3,4- thiadiazole moiety. All compounds of this series showed promising antifungal activity. It was found that some of these compounds possess marked antifungal properties comparable in efficiency to the reference drug Flukanazole. In present study the structures of compounds were confirmed by IR, UV 1H NMR and elemental analysis.
KEYWORDS:
4-(phenylamino)benzoicacid; 5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-amine derivatives; fungicide; C. albican, A. niger and IR, UV 1H NMR spectroscopy.
Cite:
Anoop Singh, A.C. Rana. Synthesis of Some New 5-(4-(Phenylamino) Phenyl)-1, 3, 4-Thiadiazol-2-Amine Derivatives as Potent Antifungal Agents. Asian J. Research Chem. 4(2): February 2011; Page 221-226.
[View HTML]      [View PDF]



Visitor's No. :   112705