Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   237-240

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of New Chalcone Analogs



Address:   H.V. Shahare*, G.R. Pawar, S.S. Patil and P.D. Patil
Department of Pharmaceutical Chemistry, SNJB’S Shriman Sureshdada Jain College of Pharmacy, Chandwad, Nashik, MS, India-423101
*Corresponding Author
DOI No:

ABSTRACT:
The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic-resistant pathogens, fueling an ever-increasing need for new drugs. In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of bromo and chloro acetophenone with appropriate aromatic aldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by their physical constants, TLC, IR and NMR spectroscopy. Further all the synthesized compounds were successfully evaluated for their antibacterial and antifungal activities by cup-plate method.
KEYWORDS:
Chalcone, Claisen-Schmidt condensation, Antimicrobial activity, Styryl ketone.
Cite:
H.V. Shahare, G.R. Pawar, S.S. Patil, P.D. Patil. Synthesis and Biological Evaluation of New Chalcone Analogs. Asian J. Research Chem. 4(2): February 2011; Page 237-240.
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