Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   254-256

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Clopidogrel Bisulphate in Pharmaceutical Dosage Forms by RP- HPLC



Address:   B. Anupama1*, V. Jagathi1 and A. Vishwanadh2
1.K.V.S.R.Siddhartha College of Pharmaceutical Sciences, Vijayawada – 520010, A.P, India
2.Vignan College of Pharmacy, Guntur, A.P, India
*Corresponding Author
DOI No:

ABSTRACT:
A simple and precise RP-HPLC method was developed and validated for the determination of clopidogrel bisulphate in pharmaceutical dosage forms. Chromatography was carried out using Inertsil ODS-3 column with 250x4.6mm i.d, and having 5µ particle size was used. Acetonitrile:0.05%Formicacid (80:20) as the mobile phase at a flow rate 1.2 ml/min. The analyte was monitored using UV detector at 240 nm. The Retention time of the drug was 6.4min for clopidogrel bisulphate. The proposed method was found to have linearity in the concentration range of 7.5– 17.5 µg/ml. The developed method has been statistically validated and found simple and accurate in bulk and dosage forms.
KEYWORDS:
Clopidogrel bisulphate, RP‐HPLC.
Cite:
B. Anupama, V. Jagathi, A. Vishwanadh. Determination of Clopidogrel Bisulphate in Pharmaceutical Dosage Forms by RP- HPLC. Asian J. Research Chem. 4(2): February 2011; Page 254-256.
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