Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   257-259

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Substituted Imidazolones for Antibacterial and Antioxidant Activities



Address:   Uddandam Aruneswari1, Sreerama Usha rani1, M Aruna Devi2 and Galla Rajitha1*
1Institute of Pharmaceutical Tech., Sri Padmavathi Mahila Visvavidyalayam (Women’s University), Tirupati-517 502
2Trinity College of Pharmaceutical Sciences, Karimnager, A.P., India
*Corresponding Author
DOI No:

ABSTRACT:
A series of 4-(substituted benzylidene)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)-2-phenyl -1H-imidazol-5(4H)-ones were synthesized by condensation of 4-benzylidene-2-phenyl-oxazol-5-one with 2-amino-5-phenyl-1,3,4-thiadiazoles in presence of sodium acetate in glacial acetic acid. The intermediate 4-benzylidene-2-phenyl-oxazol-5-ones were prepared by condensing benzaldehydes with benzoyl glycine in presence of acetic anhydride and sodium acetate. The chemical structures of synthesized compounds were confirmed by means of IR, 1H NMR. All the compounds (10-18) were screened for antibacterial and antioxidant activities. Among all, the compounds 12, 16 exhibited highest antibacterial activity against all the four strains. Compound 12 exhibited highest nitric oxide scavenging activity and most of these compounds showed significant DPPH scavenging activity.
KEYWORDS:
Imidazolone, antibacterial activity, antioxidant activity.
Cite:
Uddandam Aruneswari, Sreerama Usha rani, M Aruna Devi, Galla Rajitha. Synthesis and Evaluation of Substituted Imidazolones for Antibacterial and Antioxidant Activities. Asian J. Research Chem. 4(2): February 2011; Page 257-259.
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