Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   278-281

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole



Address:   Alok Pandey1*, Shekhar Verma2, Ravindra Dhar Dubey2, Dhansay Dewangan1, Vidyanand Patel2 and Keshav Deshmukh2
1Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52 Tamilnandu, India
2Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur - 492101(C.G.), India
*Corresponding Author
DOI No:

ABSTRACT:
Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats.
KEYWORDS:
Schiff base, 1, 3, 4-thiadiazole, Analgesic, Anti-inflammatory activity.
Cite:
Alok Pandey, Shekhar Verma, Ravindra Dhar Dubey, Dhansay Dewangan, Vidyanand Patel, Keshav Deshmukh. Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole. Asian J. Research Chem. 4(2): February 2011; Page 278-281.
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