Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   329-333

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some New 2, 4, 6 -Trisubstituted Pyrimidines

Address:   N. Srinath1*, Y. Rajendra Prasad2, K. Mukkanti3 and N. K. Agarwal2
1Department of Pharmacy, Acharya Nagarjuna University, Guntur - 521250
2University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530003
3Centre for Pharmaceutical Sciences, J N T University, Hyderabad – 500085
*Corresponding Author

A variety of 2-amino-4-(3'-methyl-4'-hydroxyphenyl)-6-(substituted) pyrimidines were synthesized by reacting various chalcones with guanidine hydrochloride. The required chalcones were prepared by condensation of 3'-methyl-4'-hydroxyacetophenone with various substituted aromatic / heteroaromatic aldehydes in the presence of alkali. All these compounds were characterized by IR, 1H NMR and Elemental analysis. The newly synthesized compounds were evaluated for their antimicrobial activity and some of them have shown significant activity when compared with the standard.
Pyrimidines, Synthesis, Antimicrobial activity.
N. Srinath, Y. Rajendra Prasad, K. Mukkanti, N. K. Agarwal. Synthesis and Antimicrobial Activity of Some New 2, 4, 6 -Trisubstituted Pyrimidines. Asian J. Research Chem. 4(2): February 2011; Page 329-333.
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