Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  2

Year :  2011

Pages :   203-205

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of High Performance Thin Layer Chromatography for the Estimation of Ziprasidone in Capsule Dosage Form



Address:   Patel A. B.1* and Patel S. G.2
1 Kalol institute of pharmacy college, Kalol, Gujarat, India
2Baroque Pharmaceutical Pvt. Ltd, Khambhat, Anand, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
A new simple, sensitive and precise high performance thin layer chromatographic method has been developed for estimation of Ziprasidone in capsule dosage form. In this method pre coated silica gel 60 GF 254 TLC plate was used as stationary phase and the chromatogram was developed using Toluene: methanol (80:20) (v/v) as mobile phase. Ziprasidone showed Rf values at 0.41 ± 0.2. The plate was scanned at 190-360nm and quantified at nm using Camag TLC Scanner. The linear concentration 400 – 2200 ng / band for ziprasidone. The percentage recovery for Ziprasidone was found to be 99.63%. The limit of detection and limit of quantitation was 6.65 ng/band, 20.14 ng/ band for Ziprasidone respectively. The method is validated as per ICH guidelines.
KEYWORDS:
Ziprasodone, HPTLC.
Cite:
Patel A. B., Patel S. G.. Development and Validation of High Performance Thin Layer Chromatography for the Estimation of Ziprasidone in Capsule Dosage Form. Asian J. Research Chem. 4(2): February 2011; Page 203-205.
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