Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method

S. A. Shah; M. P. Vaghela; B. P. Marolia; K. L. Daxina

Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   415-418

ISSN Print :  0974-4169

ISSN Online :  0974-4150

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Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method

S. A. Shah, M. P. Vaghela, B. P. Marolia, K. L. Daxina

meggy_142@rediffmail.com

Address:

S. A. Shah, M. P. Vaghela*, B. P. Marolia and K. L. Daxina
Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, 394 350, Gujarat, India
*Corresponding Author

DOI No:

ABSTRACT:

Accurate, precise, rapid and economical method was developed for the estimation of Cefixime and Ofloxacin in tablet dosage form. The first order derivative spectroscopy wavelengths selected for quantitation were 312. 0 nm for Cefixime (zero cross for Ofloxacin) and 358. 2 nm for Ofloxacin (zero cross for Cefixime). In this method linearity for detector response was observed in the concentration range of 5-40 µg/ml for both Cefixime and Ofloxacin. The proposed method was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.

KEYWORDS:

Cefixime; Ofloxacin; Derivative spectroscopy.

Cite:

S. A. Shah, M. P. Vaghela, B. P. Marolia, K. L. Daxina. Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method. Asian J. Research Chem. 4(3): March 2011; Page 415-418.

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