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Asian Journal of Research in Chemistry
ISSN: 0974-4150(Online), 0974-4169(Print)
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Journal :
Asian Journal of Research in Chemistry
Volume No. :
4
Issue No. :
3
Year :
2011
Pages :
415-418
ISSN Print :
0974-4169
ISSN Online :
0974-4150
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Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method
S. A. Shah
,
M. P. Vaghela
,
B. P. Marolia
,
K. L. Daxina
meggy_142@rediffmail.com
Address:
S. A. Shah, M. P. Vaghela*, B. P. Marolia and K. L. Daxina
Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, 394 350, Gujarat, India
*Corresponding Author
DOI No:
ABSTRACT:
Accurate, precise, rapid and economical method was developed for the estimation of Cefixime and Ofloxacin in tablet dosage form. The first order derivative spectroscopy wavelengths selected for quantitation were 312. 0 nm for Cefixime (zero cross for Ofloxacin) and 358. 2 nm for Ofloxacin (zero cross for Cefixime). In this method linearity for detector response was observed in the concentration range of 5-40 µg/ml for both Cefixime and Ofloxacin. The proposed method was successfully applied for the simultaneous determination of both drugs in commercial tablet preparation. The results of the analysis have been validated statistically and by recovery studies.
KEYWORDS:
Cefixime; Ofloxacin; Derivative spectroscopy.
Cite:
S. A. Shah, M. P. Vaghela, B. P. Marolia, K. L. Daxina. Simultaneous Estimation of Cefixime and Ofloxacin by Derivative Spectroscopy Method. Asian J. Research Chem. 4(3): March 2011; Page 415-418.
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