Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   434-436

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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RP-HPLC Method for the Estimation of Atorvastatin Calcium in Bulk and Pharmaceutical Formulations



Address:   P. Nagaraju1*, B. Sridhar2, P. Jitendra Kumar3, U. Upendra rao1, K. Hanumantha Rao2 and P.N.V. Gopal1
1Hindu College of Pharmacy, Amaravathi Road, Guntur – 522 002, Andhra Pradesh
2DCRM Pharmacy College, Inkollu, Andhra Pradesh
3Siddhartha Institute of Pharmacy, Sattenapalli , Andhra Pradesh
*Corresponding Author
DOI No:

ABSTRACT:
The present work describes a simple reverse phase HPLC method for the estimation of Atorvastatin calcium in bulk and pharmaceutical formulations. The estimation was carried out on phenomenex C18 (250 × 4.6 mm, 5µ) column using a mobile phase containing of Acetonitrile: Ortho-phosphoric acid (0.1%): Tetrahydrofuran (48:0.04:52). The eluent was monitored at 244 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.
KEYWORDS:
HPLC, Validation, Atorvastatin calcium and Pharmaceutical formulation.
Cite:
P. Nagaraju, B. Sridhar, P. Jitendra Kumar, U. Upendra rao, K. Hanumantha Rao, P.N.V. Gopal. RP-HPLC Method for the Estimation of Atorvastatin Calcium in Bulk and Pharmaceutical Formulations. Asian J. Research Chem. 4(3): March 2011; Page 434-436.
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