Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  3

Year :  2011

Pages :   362-369

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Solid Phase Synthesis and Their Screening System - Review



Address:   A.K. Mishra1*, A. Gupta1, A.K. Singh2, R. Sannd1, P. Bansal1, S. Kumar1 and V. Gupta1
1National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Dept. of AYUSH Patiala, India
2National Botanical Research Institute, Rana Pratap Marg, Lucknow, India
*Corresponding Author
DOI No:

ABSTRACT:
The use of solid phase synthesis techniques has been explored as an alternative to conventional approaches for the synthesis of compounds used in the drug discovery process. Combinatorial chemistry now plays an important role in the lead discovery and hit optimization processes in the pharmaceutical world as well as in other areas of discovery chemistry. Now days this is an important technique for the development of different synthesis concepts that were intended to cover and explore the chemical space without having to prepare every individual compound. Solid phase synthesis technologies were developed in response to the increased screening capacities and target oriented lead finding. This article explains different linker, protecting group, cleavage methods used in solid phase synthesis, combinatorial libraries and screening system used in solid phase synthesis.
KEYWORDS:
Solid phase synthesis, Combinatorial chemistry, Linker, Protecting group.
Cite:
A.K. Mishra, A. Gupta, A.K. Singh, R. Sannd, P. Bansal, S. Kumar, V. Gupta. Solid Phase Synthesis and Their Screening System - Review. Asian J. Research Chem. 4(3): March 2011; Page 362-369.
[View HTML]      [View PDF]



Visitor's No. :   119855