Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   509-510

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Lead Optimization: Research Pathways in Medicinal Chemistry

Address:   Dibyajyoti Saha1* and Milan Hait2
1School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur, C.G. - 495004
2Dept. of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.
*Corresponding Author

Lead optimization employs a combination of empirical, combinatorial and rational approaches that optimize leads through continuous, multi speed process based on knowledge gained at each stage. The testing of analog series result in quantitative information that correlates changes in chemical structure to biological and pharmacological data generate to established SARs. The medicinal chemistry- lead optimization blends synthetic chemistry, molecular modeling, computational biology, structural genomics and pharmacology to discover and design new drugs and investigate their interaction at the molecular, cellular and whole animal level. The present pathways give mechanism of animal PK/PD/ADMEs highlighting the toxicity, formulation and delivery.
Lead optimization, Medicinal chemistry.
Dibyajyoti Saha, Milan Hait. Lead Optimization: Research Pathways in Medicinal Chemistry. Asian J. Research Chem. 4(4): April, 2011; Page 509-510.
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