Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   591-596

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of New 7-(3-(benzo[d]thiazol-2-ylamino) propoxy)-4-methyl-2H-chromen-2-one derivatives with Atypical Antipsychotic activity



Address:   Gawai Ashish1*, Das Sanjib1, Nemade M2 and Wathore S.2
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam- 786004, India
2TVES’s College of Pharmacy, Nehru Vidyanagar, Faizpur, M.S-425503, India.
*Corresponding Author
DOI No:

ABSTRACT:
A new series of 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives(4a-4k) were synthesized and evaluated for their D2 and 5HT2 antagonistic activity as a measure of atypical antipsychotic property. Most of these compounds showed dopamine D2 receptor antagonistic activity from moderate to high potency along with serotonin 5-HT2 receptor blockage activity. The dopamine D2 and serotonin 5-HT2 receptor blockage activity was evaluated by inhibition of apomorphine-induced climbing behavior and 5HTP induced head twitches in mice respectively. Compounds 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives (4a-4k) were synthesized by addition of various 2-amino benzothiazoles substituted derivatives (3a-3k) with 7-(3-Chloropropoxy)-4-methyl-2H-chromen-2-one(2) refluxing in dry pyridine. The synthesized compounds were characterized with the help of spectral and analytical study.
KEYWORDS:
Schizophrenia, Atypical Antipsychotics, Benzothiazole. Chromen-2-one.
Cite:
Gawai Ashish, Das Sanjib, Nemade M, Wathore S.. Synthesis of New 7-(3-(benzo[d]thiazol-2-ylamino) propoxy)-4-methyl-2H-chromen-2-one derivatives with Atypical Antipsychotic activity. Asian J. Research Chem. 4(4): April, 2011; Page 591-596.
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