Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   611-612

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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New Visible Spectrophotometric Methods for Determination of Nepafenac



Address:   B. Anupama*, D. Madhavi, S. Amareswari and CH. Hari Prasad
K.V. S. R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, AP, India.
*Corresponding Author
DOI No:

ABSTRACT:
Two simple and sensitive visible spectrophotometric methods have been developed for the estimation of Nepafenac in pure and pharmaceutical dosage forms. These methods are based on the oxidative coupling reaction between MBTH(3-Methyl-2-bezothiazolinone hydrazone) and Nepafenac resulting in the formation of pink colored chromogen ( ?max 540 nm) and the complex formation between Potassium permanganate and Nepafenac resulting in the formation of blood red colored chromogen (?max 425 nm). The absorbance is measured against the corresponding reagent blanks. These methods have been statistically evaluated and found to be precise and accurate.
KEYWORDS:
MBTH(3-Methyl-2-bezothiazolinone hydrazone), coupling, spectrophotometry.
Cite:
B. Anupama, D. Madhavi, S. Amareswari, CH. Hari Prasad. New Visible Spectrophotometric Methods for Determination of Nepafenac. Asian J. Research Chem. 4(4): April, 2011; Page 611-612.
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