Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   616-618

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Spectrophotometric Simultaneous Estimation of Salbutamol and Prednisolone in Bulk and Formulation.



Address:   Parag A. Kulkarni* and Pramod V. Kasture
Department of Pharmaceutics, Dr D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra, India
*Corresponding Author
DOI No:

ABSTRACT:
Combination of Salbutamol and Prednisolone was found effective for the treatment of acute and chronic asthma. A fast, simple and accurate method for the estimation of this combination is necessary so, two UV Spectrophotometric methods for simultaneous estimation of salbutamol (SAL) and prednisolone (PRE) have been developed in the present work. First method is Q value analysis based on measurement of absorptivity at 230nm (iso-absorptive point) and 244nm (?max for Prednisolone) as two analytical wavelengths for both drugs in methanol. Second method involves multicomponent mode of analysis, wavelength selected are 227nm (?max for Salbutamol) and 244 nm (?max for Prednisolone). All the methods show linearity in the concentration range of 6-20µg/ml for salbutamol as well as for prednisolone. The accuracy and precision of the methods were determined and validated stastically which shows no significant difference between the results obtained by the two methods. The proposed methods are rapid, simple and accurate and can be used for its intended purpose.
KEYWORDS:
Salbutamol, Prednisolone, Q - value analysis, Multicomponent mode of analysis.
Cite:
Parag A. Kulkarni, Pramod V. Kasture. Spectrophotometric Simultaneous Estimation of Salbutamol and Prednisolone in Bulk and Formulation. Asian J. Research Chem. 4(4): April, 2011; Page 616-618.
[View HTML]      [View PDF]



Visitor's No. :   106477