Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   626-628

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Microwave Assisted Facile Synthesis of Some Novel Mannich’s Bases of Isatoic Anhydide Derivatives



Address:   Veena Yadav* and Nishant Yadav
Department of Chemistry, Kurukshetra University, Kurukshetra (India)
*Corresponding Author
DOI No:

ABSTRACT:
An efficient microwave assisted protocol for the synthesis of Mannich’s bases of isatoic-anhydride derivatives 4(a-g) has been described. Treatment of isatoic anhydride (1) with formaldehyde yielded 1-hydroxymethyl-1H-benzo[d][1,3]oxazine-2,4-dione (2) followed by reaction with HCl afforded 1-chloromethyl-1H-benzo[d][1,3]oxazine-2,4dione (3) which reacted smoothly with sec. amines to give mannich’s bases 4(a-g) in excellent yield.
KEYWORDS:
Microwave assisted organic synthesis, isatoic anhydrides, sec. amines, Mannich bases.
Cite:
Veena Yadav, Nishant Yadav. Microwave Assisted Facile Synthesis of Some Novel Mannich’s Bases of Isatoic Anhydide Derivatives. Asian J. Research Chem. 4(4): April, 2011; Page 626-628.
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