Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   647-649

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Visible Spectroscopic Method for the Determination of Mesalamine in Bulk and Tablet Formulation



Address:   A. K. Moharana1*, M. Banerjee2 and N.K. Sahoo3
1Omega College of Pharmacy, Ghatkesar, R.R. Dist, 501301, Andhra Pradesh
2Institute of Pharmacy and Technology, Salipur, Cuttack, 754202, Orissa
3Yalamarty Pharmacy College, Tarluwada, Visakhapatnam, 530052, Andhrapradesh
*Corresponding Author
DOI No:

ABSTRACT:
A simple and cost effective spectrophotometric method is described for the determination of mesalamine in pure form and in pharmaceutical formulations. When the drug reacts with 0.5N HCl and freshly prepared 0.4% w/v Ferric Nitrate solution the colour changes to brown. It shows absorption maximum at 432.6 nm and obeys Beer’s law in the concentration range 50-150µg mL-1. The colouring reagent is stable when checked for its stability test; it is stable for 4 hours. The absorbance was found to increase linearly with increasing concentration of MSZ, which is corroborated by the calculated correlation coefficient value of 0.9995 (n=6). The validity of the described procedure was assessed. Statistical analysis of the result has been carried out revealing high accuracy and good precision. The proposed method was successfully applied to the determination of MSZ in pharmaceutical formulations without any interference from common excipients.
KEYWORDS:
Mesalamine (MSZ), visible spectroscopy, validation, pharmaceuticals.
Cite:
A. K. Moharana, M. Banerjee, N.K. Sahoo. Development and Validation of Visible Spectroscopic Method for the Determination of Mesalamine in Bulk and Tablet Formulation. Asian J. Research Chem. 4(4): April, 2011; Page 647-649.
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