Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   659-665

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Kinetic Estimation of Ibuprofen and Nimesulide in Pharmaceuticals

Address:   B.S. Virupaxappa1*, K.H. Shivaprasad1, Raviraj M. Kulkarni2 and M.S. Latha3
1Department of Chemistry, PG Centre, Bellary, Gulbarga University, Gulbarga, Karnataka, (INDIA)
2Department of Chemistry, Gogte Institute of Technology, Udyambag, Belgaum, Karnataka, (INDIA)
3Department of Chemistry, G M Institute of Technology Davangere, Karnataka, (INDIA)
*Corresponding Author

Simple Kinetic Spectrophotometric methods have been developed and validated for the estimation of Anti inflammatory drugs, namely Ibuprofen and Nimesulide in pharmaceutical dosage forms. The method is based on the oxidation of Ibuprofen and Nimesulide with alkaline potassium permanganate. In alkaline medium permanganate (Mn+7) oxidizes Ibuprofen and Nimesulide undergoes one electron reduction to give a green colored manganate ions (Mn+6) which has wavelength maximum at 610 nm, and unreacted permanganate at 526 nm. The Fixed time (at 240 sec) and Rate constant method were utilized for constructing the calibration graphs. The calibration graphs are linear in the concentration ranges from 30.8–308 µgmL-1 and 20.6 – 206 µgmL-1 using the Fixed time methods and Rate constant methods respectively. The results are validated statistically and checked through recovery studies. The method has been successfully applied for the determination of the studied Anti inflammatory drugs in commercial dosage forms.
Ibuprofen, Nimesulide, Kinetic spectrophotometry, Fixed time method, Rate constant method.
B.S. Virupaxappa, K.H. Shivaprasad, Raviraj M. Kulkarni, M.S. Latha. Kinetic Estimation of Ibuprofen and Nimesulide in Pharmaceuticals. Asian J. Research Chem. 4(4): April, 2011; Page 659-665.
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