Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  4

Year :  2011

Pages :   671-677

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Biological Cytotoxicity Evaluation of Sulfonamide Derivatives as Anti-Lung and Anti-Breast Cancer Activity



Address:   Sarav A. Desai 1*, Prakash S. Sukhramani2, Maulik P. Suthar3 and Vipul P. Patel3
1Pioneer Pharmacy College, Ajwa Road, Nr. N.H. 8, Sayajipura, Vadodara, Gujarat, India
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi, Dist: Kutch – 370460, Gujarat, India
3 Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana – Gozaria Highway, Kherva – 382711, Ta and Dist: Mehsana (N.G.), India
*Corresponding Author
DOI No:

ABSTRACT:
The purpose of this research work was to evaluate the cytotoxic activity of Sulfonamide derivatives against the panel of lung cancer and breast cancer cell lines, which were MDAMB-453, MCF-7, MDAMB-468, NCI-H23, and NCI-H522 with one normal cell lines, which was HEK-293T (Human embryonic kidney cell line); by comparing the results with the standard drug Doxorubicin. For primary screening, sulfonamide derivatives were screened at 100 µM concentration against all cell lines with the use of XTT based cytotoxicity assay and the compounds which were found to be active as a anti-cancer and those with lower IC50 value below 60 µM were again subjected to MTT assay for confirmation. From the results, Compound No. 1 having substitution with chlorine group showed cytotoxicity against panel of breast cancer cell lines (IC50 = 48.39 µM in MCF-7, IC50 = 36.86 µM in MDA-MB453 and IC50 = 38.52 µM in MDA-MB468) but it is found to be inactive against lung cancer cell lines with no activity in normal cell line.
KEYWORDS:
Sulfonamide, Lung and Breast cancer, MTT Bio-assay, XTT Bio-assay.
Cite:
Sarav A. Desai , Prakash S. Sukhramani, Maulik P. Suthar, Vipul P. Patel. Biological Cytotoxicity Evaluation of Sulfonamide Derivatives as Anti-Lung and Anti-Breast Cancer Activity. Asian J. Research Chem. 4(4): April, 2011; Page 671-677.
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