Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   757-760

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Pharmacology of Some Aryloxypropanolamine Derivatives

Address:   S. B. Jadhav1* and P. Y. Shirodkar2
1Department of Pharmaceutical Chemistry, P.E.S.’s Modern College of Pharmacy, Nigdi, Pune – 411 044
2Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra
*Corresponding Author

4-hydroxy-3-methoxy benzaldehyde on reaction with substituted anilines gave imine compounds (2a-d) which on reaction with epichlorhydrin gave epoxides (3a-d). These compounds on reaction with amines gave 1-(2-methoxy-4-arylimino phenoxy)-3-(substituted amino)-propan-2-ol (4a-h). All newly synthesized compounds were characterized on the basis of spectral analysis and evaluated for ß-blocking activity. Compound (4e) was found to be most potent compound of this series and was compared with the reference drug, propranolol. Other compounds in this series were found to possess varied degree of ß-blocking activity.
Aryloxypropanolamines, β-blocking activity.
S. B. Jadhav, P. Y. Shirodkar. Synthesis and Pharmacology of Some Aryloxypropanolamine Derivatives. Asian J. Research Chem. 4(5): May, 2011; Page757-760.
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