Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   766-769

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antimicrobial Activity of Some Novel 2, 5-Di substituted 1, 3, 4-Oxadiazole Derivatives



Address:   B.H. Kilarimath1, V.G. Digge2*, S.S. Honnali3, R.M. Sankangoud4, P.C. Jalihal5 and Sonjoy Mandal1
1Bapuji Pharmacy College, Davangere, Karnataka, India.
2Shivlingeshwar College of Pharmacy, Hasegaon, Maharashtra.
3KLE University’s College of Pharmacy, Hubli, Karnataka.
4KLES’s College of Pharmacy, Nipani, Karnataka.
5HSK College of Pharmacy, Bagalkot, Karnataka.
*Corresponding Author
DOI No:

ABSTRACT:
A series of 5-{2-[(substituted phenyl) amino] ethyl}-1, 3, 4-oxadiazole-2-thiol (IIIa-i) derivatives were synthesized by the reaction of 3-[(substituted phenyl) amino] propanehydrazide (IIa-i) with carbon disulphide in presence alc. KOH. Structures of the compounds were confirmed by the spectral data such as IR, 1H-NMR. All the synthesized compounds were tested against a panel of gram positive, gram negative bacteria and fungi using cup-plate-agar diffusion method. Some compounds shown promising activity.
KEYWORDS:
gram positive, gram negative, antifungal activity, antimicrobial screening, oxdiazole.
Cite:
B.H. Kilarimath, V.G. Digge, S.S. Honnali, R.M. Sankangoud, P.C. Jalihal, Sonjoy Mandal. Synthesis and Antimicrobial Activity of Some Novel 2, 5-Di substituted 1, 3, 4-Oxadiazole Derivatives. Asian J. Research Chem. 4(5): May, 2011; Page 766-769.
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