Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   779-785

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Release Dynamics of Tetracycline from a Loaded Hydrgel of Gelatin, Sodium Salt of 2- Acrylamido-2-Methyl Propane Sulfonic Acid and Acryl Amide



Address:   Arandao Narzary and Nirada Devi*
Department of Chemistry, Cotton College, Guwahati- 781001, Assam, India
*Corresponding Author
DOI No:

ABSTRACT:
A novel hydrogel composed of gelatin, sodium salt of 2- acrylamido-2-methyl propane sulfonic acid (Na-AMPS), and acryl amide (AM) was using N,N-methylenebisacrylamide(MBA) as crosslinker and Potassium peroxodisulfate (KPS) as initiator in aqueous medium. The influence of various parameters on the equilibrium swelling ratio of the hydrogel was investigated. The drug release kinetics of the hydrogel loaded with tetracycline(TC) was studied at 370. The results obtained during experimental analysis showed that molar amount in cross linking agent as well as the the monomers greatly affected the swelling ratio of the hydrogel and release kinetics of the model drug. The equilibrium release percent of TC reached about 80% release after 96 hours and the fractional release rate was controlled by the swelling of the hydrogel.
KEYWORDS:
Hydrogel; AMPS; Gelatin; Sustained drug release.
Cite:
Arandao Narzary, Nirada Devi. Release Dynamics of Tetracycline from a Loaded Hydrgel of Gelatin, Sodium Salt of 2- Acrylamido-2-Methyl Propane Sulfonic Acid and Acryl Amide. Asian J. Research Chem. 4(5): May, 2011; Page 779-785.
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