Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   795-799

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A New Simple RP-HPLC Method for Simultaneous Estimation of Asprin, Atorvastatin and Clopidogrel in Capsule Dosage Form



Address:   Devika G.S. 1*, M. Sudhakar1, J. Venkateshwara Rao2
1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maissamaguda, Dullapally, Secunderabad -14, Andrapradesh, India.
2Department of Pharmaceutical Chemistry, Sultan Ul Uloom College of Pharmacy, Road No3, Banjara Hills , Secunderabad- 500034, Andra pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
The working conditions for the high pressure liquid Chromatography method was established for Asprin, Atorvastatin and Clopidogrel and then applied on pharmaceutical dosage forms. A rapid sensitive of Chromarographic separation was accomplished using hypersil BDS C18 (250×4.6 mm, 5µ ) analytical column with mobile phase consisting of, acetonitrile, water (pH 3)and methanol (50:40:10 v/v). The eluent were detected by UV absorbance at 248 nm. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification and solution stability. The proposed method can be used for the estimation of these drugs in combined pharmaceutical dosage forms.
KEYWORDS:
Simultaneous estimation, asprin, atorvastatin, clopidogrel.
Cite:
Devika G.S., M. Sudhakar, J. Venkateshwara Rao. A New Simple RP-HPLC Method for Simultaneous Estimation of Asprin, Atorvastatin and Clopidogrel in Capsule Dosage Form. Asian J. Research Chem. 4(5): May, 2011; Page 795-799.
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