Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  5

Year :  2011

Pages :   802-804

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, Characterization and Biological Activities of New (5' Phenyl isoxazolinyl thio) 8-substituted (1, 2, 4) triazino (5, 6 b) indole Derivatives



Address:   Manju S.V.*, Francis.S, Nina Varghese and Rashmi Mathews.
Department of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Thirumenahalli, Hedgenagar Main Road, Bangalore North, Karnataka.
*Corresponding Author
DOI No:

ABSTRACT:
A new series of (5' Phenyl isoxazolinyl thio) 8-substituted (1, 2, 4) triazino (5, 6 b) indole derivatives were synthesized and evaluated for their antimicrobial and analgesic activities. Different 5-substituted isatins was treated with thiosemicarbazide to form 5-substituted derivatives of isatin 3-thiosemicarbazone (Comp1a-e) which when refluxed with 4 % KOH for 4 hrs gave the 8-substituted 5H - 2,3 dihydro (1,2,4) triazino (5,6 b) indole 3-thione (Comp 2a-e) which on treatment with cinnamoyl chloride resulted in the formation of 5H-3-(cinnamoyl thio)- 8- substituted (1,2,4) triazino (5,6-b) indole (Comp3a-e) which on further refluxing with hydroxylamine hydrochloride, sodium acetate and ethanol for 6 hrs resulted in the formation of 5H-3-(5' phenyl isoxazolinyl thio) 8- substituted (1,2,4) triazino (5,6 b) indole(Comp 4 a-e).The purity of the compounds monitored by TLC. The structures were confirmed on the basis of IR, 1H NMR spectra. Among the synthesized compounds few compounds have shown promising antibacterial, antifungal, and analgesic activity.
KEYWORDS:
Antimicrobial, Triazine, Isoxazole, Analgesic.
Cite:
Manju S.V., Francis.S, Nina Varghese, Rashmi Mathews. Synthesis, Characterization and Biological Activities of New (5' Phenyl isoxazolinyl thio) 8-substituted (1, 2, 4) triazino (5, 6 b) indole Derivatives. Asian J. Research Chem. 4(5): May, 2011; Page 802-804.
[View HTML]      [View PDF]



Visitor's No. :   125957