Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   896-897

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Adaptation of Color Reactions for Spectrophotometric Determination of Mosapride Citrate in Formulations



Address:   Srinivasa Rao Narala1* and K. Saraswathi2
1Department of Chemistry, R.V.R. & J.C. College of Engineering, Guntur, A.P., India.
2 Department of Chemistry, S.V. University, Tirupathi, A.P., India.
*Corresponding Author
DOI No:

ABSTRACT:
Three new, simple and sensitive visible spectrophotometric methods (A, B and C) have been developed for the determination of Mosapride Citrate in bulk drug and pharmaceutical formulations. Method A is based on the condensation of Mosapride Citrate with salicylaldehyde to form schiff’s base, which was a yellow colored chromogen exhibiting ?max at 410 nm. Method B is based on the formation of pink colored chromogen obtained when Mosapride Citrate was diazotized with nitrous acid followed by coupling with a-naphthyl amine, exhibiting ?max at 520 nm. Method C is based on the oxidation of Mosapride Citrate with Fe (III) and the estimation of Fe (II) produced after chelation with potassium ferricyanide, which was a bluish green colored chromogen, exhibiting ?max at 770 nm. The Beer’s law was obeyed in the concentration range of 4-20, 10-40 and 4-24 µg/ml for methods A, B and C respectively. The results of the proposed methods have been validated statistically and by recovery methods.
KEYWORDS:
spectrophotometry, salicylaldehyde, α-naphthyl amine, potassium ferricyanide.
Cite:
Srinivasa Rao Narala, K. Saraswathi. Adaptation of Color Reactions for Spectrophotometric Determination of Mosapride Citrate in Formulations. Asian J. Research Chem. 4(6): June, 2011; Page 896-897.
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