Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   902-904

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antitumor Activity of Combretastatin Analogues



Address:   Sunil Kumar1, Surrinder Koul2, Ajay Kumar Meena4, A.K. Saxena3, O.P. Suri1 and K.L. Dhar1*
1Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001, India
2Department of Bio-organic Chemistry, IIIM Jammu Tawi 180001, India
3Division of Pharmacology, IIIM Jammu Tawi, 180001 India
4National Institute of Ayurvedic Pharmaceutical Research, Moti Bagh Road, Patiala, India.
*Corresponding Author
DOI No:

ABSTRACT:
Plants, source of various bioactive compounds have played crucial role in development of several clinically useful anticancer agents’ viz., vincristin, vinblastin, camptothecin derivatives and taxol. Combretastatin, a potent anticancer molecule was first isolated from plant. In this continuation a series of combretastatin analogues has been synthesized on the basis of our butterfly model with two wings as aryl groups and connecting carbon chain as the body. In present study we have synthesized combretastatin analogues of different substitutions, showed potent anticancer activity against different cell lines in different fashion according to substitution. Compound 6 showed marked anticancer activity against colo-205 cell lines (colon cancer).
KEYWORDS:
Combretastatin; antitumor; phenyl acetic acid; tubulin inhibitor.
Cite:
Sunil Kumar, Surrinder Koul, Ajay Kumar Meena, A.K. Saxena, O.P. Suri, K.L. Dhar. Synthesis and Antitumor Activity of Combretastatin Analogues. Asian J. Research Chem. 4(6): June, 2011; Page 902-904.
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