Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   905-907

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Formoterol Fumarate and Budesonide in Combined Dosage Form



Address:   Mohd. Gousuddin*, S. Appala Raju, Sultanuddin, Shobhamanjunath
Dept. of Pharmaceutical Analysis, H.K.E. Society’s College of Pharmacy, Sedam Road, Gulbarga-585 105 (K.S.) India.
*Corresponding Author
DOI No:

ABSTRACT:
Asimple, accurate, cost effective and reproducible spectrophotometric method; Q Analysis (Absorbanceratio), has been developed for the simultaneous estimation of formoterol fumarate and Budesonide in rotocap dosage form. Method involves formation of ‘Q-absorbance Equation’ at 257.0 nm (?max of formoterol fumarate) and 278.0 nm (isoabsorptive point) in distilled water. Beer’s law were obeyed (at isoabsorptive point) in the concentration range of 2-20µg /ml for formoterol fumarate having line equation y=0.04950x+0.03520 with correlation coefficient of 0.99987 and 4-40µg/ ml for Budesonide having line equation y=0.10246x+0.03990 with correlation coefficient of 0.99925. The developed method was validated as per ICH guide lines with respect to linearity, accuracy (recovery), precision and specificity.The percentage recovery of formoterol fumarate ranged from (98.67±0.2421) and Budesonide ranged from (98.54±0.3330) in tablet dosage form. By treating the data statistically and by recovery study, results of study were validated.
KEYWORDS:
spectrophotometric simultaneous estimation, formoterol fumarate (FF) Budesonide (BD), Q-Analysis, Absorbance ratio.
Cite:
Mohd. Gousuddin, S. Appala Raju, Sultanuddin, Shobhamanjunath. Simultaneous Spectrophotometric Estimation of Formoterol Fumarate and Budesonide in Combined Dosage Form. Asian J. Research Chem. 4(6): June, 2011; Page 905-907.
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