Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  6

Year :  2011

Pages :   1009-1013

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Some New Benzofuran Derivative for Antimicrobial Activity

Address:   Ramesh V.1*, S.M. Shantakumar2 and M. Bhagavanraju2
1Department of Pharmaceutical Chemistry, K.L.E. College of Pharmacy, K.L.E University, Belgaum-590010
2Department of Pharmaceutical chemistry, V.L. College of Pharmacy, Raichur-584101
*Corresponding Author

Most of the diseases in the current scenario are found to be due to infections caused by microbes like bacteria, fungi, rickettsia, etc. Many antibiotics have been discovered till date for treatment of such diseases but most of them are associated with superinfection, development of resistance, destruction of normal non pathogenic bacterial flora and selective toxicity like aplastic anemia, kidney damage etc. The present study is based upon preparation of antibiotics with high potency, specificity and less toxicity. Benzofuran derivatives are widely distributed in nature and they have been shown to have very interesting pharmacological activities like, antibacterial, anti-inflammatory and anti fungal. When one biologically active molecule is linked to another, the resultant molecule generally has increased potency. Hence in the present study the two pharmacophores, benzofuran and Mercaptotriazoles are fused to obtain highly potent, more specific and less toxic antibiotics.
Antifungal activity, antimicrobial activity, anti-inflammatory, anti-depressant, analgesic activity, hypoglycemic activity.
Ramesh V., S.M. Shantakumar, M. Bhagavanraju. Synthesis and Evaluation of Some New Benzofuran Derivative for Antimicrobial Activity. Asian J. Research Chem. 4(6): June, 2011; Page 1009-1013.
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