Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  7

Year :  2011

Pages :   1077-1080

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A New RP-HPLC Method for the Simultaneous Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Formulation



Address:   D. Boopathy*, B. Arun Kumar, Devaki Magham, V. Sekar and P. Perumal.
Department of Pharmaceutical Analysis, J.K.K. Nattraja College of Pharmacy, Komarapalayam- 638 183, Namakkal (D.T), Tamil Nadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure is developed for simultaneous determination of Rabeprazole sodium and Itopride hydrochloride in Capsule dosage form. The mobile phase used was a combination of methanol: buffer (65:35 v/v) and the pH was found to be 4.30. The detection of the capsule dosage form was carried out at 285 nm and the flow rate employed was 1 mL/min. Linearity was obtained in the concentration range of 2.5 to 15 µg/mL of Rabeprazole sodium and 20 to 120 µg/mL of itopride hydrochloride with a correlation coefficient of 0.998 and 0.996 respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Rabeprazole sodium(RS), Itopride hydrochloride(IH), HPLC.
Cite:
D. Boopathy, B. Arun Kumar, Devaki Magham, V. Sekar, P. Perumal. A New RP-HPLC Method for the Simultaneous Estimation of Rabeprazole Sodium and Itopride Hydrochloride in Formulation. Asian J. Research Chem. 4(7): July, 2011; Page 1077-1080.
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