Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  7

Year :  2011

Pages :   1114-1118

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Extractive Spectrophotometric Methods for Determination of Tamsulosin HCl in Pharmaceutical Formulations Using Acidic Triphenyl Methane Dyes



Address:   Susmitha K.2, Radha K.2 and Venkateshwarlu G.1*
1Department of Chemistry, Nizam College, Hyderabad -500001, A.P. India
2Department of Chemistry, St. Anns College for Women, Hyderabad -500028, A.P. India
*Corresponding Author
DOI No:

ABSTRACT:
Four simple and sensitive extractive spectrophotometric methods have been described for the assay of Tamsulosin hydrochloride either in pure form or in pharmaceutical formulations. The developed methods involve formation of colored chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB), bromocresol purple (BCP) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 415 nm for all four methods. Beer’s law is obeyed in the concentration ranges 2.5-25, 2.5-25, 2.0 - 25 and 2.5 - 25. µg/ml with BTB, BPB, BCP and BCG, respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for four methods. All the four methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies.
KEYWORDS:
Tamsulosin hydrochloride; Bromothymol blue; Bromophenol blue; Bromocresol green; Bromocresol purple, Spectrophotometry.
Cite:
Susmitha K., Radha K., Venkateshwarlu G.. Extractive Spectrophotometric Methods for Determination of Tamsulosin HCl in Pharmaceutical Formulations Using Acidic Triphenyl Methane Dyes. Asian J. Research Chem. 4(7): July, 2011; Page 1114-1118.
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