Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  7

Year :  2011

Pages :   1119-1124

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method.



Address:   Varsha Balkrishna Mane*, Surekha Babar, Karishma Waghmare and Anita S. Kulkarni
Government College of Pharmacy, Vidyanagar, Karad (MS)
*Corresponding Author
DOI No:

ABSTRACT:
A versatile, accurate, precise and economic method for simultaneous determination of Domperidone and Omeprazole in fixed dose combination products was developed. The absorbance values at 284.8 nm and 301.2 nm and 290.9nm (isoabsorptive point) were used for the estimation of Domperidone and Omeprazole, respectively without mutual interference. This method obeyed Beer’s law in the concentration range of 18–28 µg /ml for Domperidone and 5-30 µg/ml for Omeprazole. The results of analyses have been validated statistically for linearity, accuracy and precision, LOD and LOQ of the proposed method.
KEYWORDS:
Domperidone, Omeprazole, Dimetyl formamide, distilled water, ultraviolet spectrophotometry.
Cite:
Varsha Balkrishna Mane, Surekha Babar, Karishma Waghmare, Anita S. Kulkarni. Development of UV Spectrophotometric Method for the Simultaneous Estimation of Domperidone and Omeprazole in Capsule Dosage Form by Simultaneous Equation and Absorbance Ratio Method. Asian J. Research Chem. 4(7): July, 2011; Page 1119-1124.
[View HTML]      [View PDF]



Visitor's No. :   126924