Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  7

Year :  2011

Pages :   1141-1147

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Simultaneous Estimation of Paracetamol, Caffeine, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Loratadine in Tablet Dosage form by RP-HPLC.



Address:   Lohar V.R.1*, Mane Aruna2, Chavan jaykar2, Palled M.S.1 and Bhat A.R.1
1Department of Pharmaceutical Chemistry, KLEU’s College of Pharmacy, JNMC Campus, Nehrunagar, Belgaum-10, Karnataka, India.
2Quality Assurance and Technical Services, Okasa Pharma Pvt. Ltd., Satara, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, selective, rapid, precise and economical RP HPLC method has been developed for the determination of Paracetamol, Caffeine, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Loratadine in tablet formulation. The analysis was resolved by using a mobile phase (Sodium heptane sulphonate buffer solution and Acetonitrile in the ratio of 95:5) at a flow rate of 1ml/min on an gradient consisting of Shimadzu LC 2010 HPLC system on variable wavelength UV detector using, Inertsil ODS 3V (4.6 mm x 5 cm, 3 µm) column at a wavelength of 205 nm. The retention time were found to be Paracetamol (3.5min), Caffeine (5.5min), Pseudoephedrine HCl (8min), Dextromethorphan HBr (14min), Loratadine (15min). The percent recovery of Paracetamol, Caffeine, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Loratadine were found to be in between 98% to 102%. The developed method was simple, precise, accurate and reproducible and therefore suitable for routine analysis of drugs in tablet dosage form.
KEYWORDS:
Paracetamol, Caffeine, Pseudoephedrine HCl, Dextromethorphan HBr, Loratadine.
Cite:
Lohar V.R., Mane Aruna, Chavan jaykar, Palled M.S., Bhat A.R.. Simultaneous Estimation of Paracetamol, Caffeine, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide and Loratadine in Tablet Dosage form by RP-HPLC. Asian J. Research Chem. 4(7): July, 2011; Page 1141-1147.
[View HTML]      [View PDF]



Visitor's No. :   119855