Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1258-1261

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Vierodt’s and Q-Absorption Ratio Spectrophotometric Methods for Simultaneous Determination of Drotaverine Hydrochloride and Paracetamol in Tablet Dosage Form



Address:   A.J.Vyas1*, J.K. Patel2, J.R. Chavda3, A. Bhandari1 and N.R. Seth4
1Jodhpur National University, Jodhpur, India.
2Nootan College of Pharmacy, Visnagar, Gujarat, India.
3B.K. Mody Govt. Pharmacy College Rajkot, India.
4Department of Pharmaceutical Sceience, Saurastra University, Rajkot, India.
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, accurate, precise, sensitive and economical spectrophotometric methods; Vierodt’s method and Q Absorption ratio method have been described for the simultaneous estimation of drotaverine hydrochloride (DROT) and paracetamol (PCM) in combined tablet dosage form. Absorption maxima of drotaverine hydrochloride and paracetamol in 0.05 N NaOH was found to be 230.4 nm and 257 nm respectively. Drotaverine hydrochloride and Paracetamol obey Beer’s law in the concentration range 2-80 µgmL-1 (r2=0.9996) and 2-30 µgmL-1 (r2=0.9997) in 0.05 N NaOH and mean recovery for drotaverine hydrochloride and paracetamol were found to be 100.75±0.74% and 100.27 ±0.70%, respectively. Q absorption ratio method employs 238.8 nm as ?1 (Isobestic point) and 257 nm as ?2 (?max of Paracetamol) for formation of equations. Drotaverine hydrochloride and paracetamol obey Beer’s law in the concentration range 2-80 µgmL-1 (r2=0.9993) and 2-30 µgmL-1 (r2=0.9997) in 0.05 N NaOH. The mean recovery for Drotaverine hydrochloride and Paracetamol were found to be 100.47 ± 0.10% and 100.006 ± 0.136%. The results of two methods were validated statistically and can be successfully applied for the routine analysis of drotaverine hydrochloride and paracetamol in bulk and combined tablet dosage form.
KEYWORDS:
Drotaverine hydrochloride, paracetamol, vierodt’s method, Q Absorption ratio method, spectrophotometry.
Cite:
A.J.Vyas, J.K. Patel, J.R. Chavda, A. Bhandari, N.R. Seth. Vierodt’s and Q-Absorption Ratio Spectrophotometric Methods for Simultaneous Determination of Drotaverine Hydrochloride and Paracetamol in Tablet Dosage Form. Asian J. Research Chem. 4(8): August, 2011; Page 1258-1261.
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