Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1275-1277

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Simple Method for the Spectrophotometric Determination of Cefixime in Pharmaceuticals



Address:   B.S. Virupaxappa1*, K.H. Shivaprasad1, and Latha M. S.2
1Department of Chemistry PG Centre, Bellary, Gulbarga University, Gulbarga, Karnataka, (INDIA)
2Department of chemistry, GM Institute of Technology, Davangere, Karnataka, (INDIA)
*Corresponding Author
DOI No:

ABSTRACT:
A simple spectophotometric method for the determination of Cefixime with Methylene blue is presented. The determination is based on the hydrolysis of ß-lactum ring of Cefixime with sodium hydroxide which subsequently reacts with iodate to liberate iodine in acidic medium. The liberated iodine oxidizes Methylene blue to violet colored species of maximum absorption at 640 nm. The absorption is measured within the pH range of 4.1-4.4. Beer’s law is obeyed in the range of 0.5-7.9 µg/mL for Cefixime. The analytical parameter was optimized and the method is successfully applied for the determination of Cefixime.
KEYWORDS:
Cefixime, spectrophotometry, Methylene blue.
Cite:
B.S. Virupaxappa, K.H. Shivaprasad, Latha M. S.. A Simple Method for the Spectrophotometric Determination of Cefixime in Pharmaceuticals. Asian J. Research Chem. 4(8): August, 2011; Page 1275-1277.
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