Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1311-1317

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Determination of Drugs Using p-Chloranilic Acid as Analytical Reagent



Address:   K. Damodar Reddy, Sayaji Rao and G. Venkateshwarlu*
Department of Chemistry, Nizam College. Hyderabad, 500 001, India
*Corresponding Author
DOI No:

ABSTRACT:
Six drugs viz., Metoprolol tartrate, Torsemide, Diclofenac sodium, Chlorpheniramine, Loratadine and irbesartan were tested for the formation of charge transfer complexes with p-CA and the interaction formed a basis for quantitative determination of the drugs spectrophotometrically. CH3CN was found to be suitable for the analysis. The methods have been validated in terms of ICH guidelunes The complexes were found to have 1:1 composition and have stability of the order 10 5.
KEYWORDS:
Spectrophotometry, p-CA, Drug, quantification, validation.
Cite:
K. Damodar Reddy, Sayaji Rao, G. Venkateshwarlu. Spectrophotometric Determination of Drugs Using p-Chloranilic Acid as Analytical Reagent. Asian J. Research Chem. 4(8): August, 2011; Page 1311-1317.
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