Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1206-1209

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Estimation of Rosuvastatin Calcium in Tablet Dosage Form by HPTLC Method

Address:   V.V. Karkhanis*, Vikas Parikh and Roma Panchal
A.R. College of Pharmacy and G.H. Patel institute of Pharmacy, Vallabh Vidyanagar -388 120, Dist. Anand, Gujarat
*Corresponding Author

A simple, precise, accurate and rapid high-performance thin-layer chromatographic method has been developed for the estimation of Rosuvastatin calcium in tablet dosage forms. The stationary phase used was pre-coated silica gel 60 F254. The mobile phase used was a mixture of Acetonitrile: Ethyl Acetate: Toluene (6:1:3 v/v/v). The detection of spots was carried out at 245 nm. The calibration curve was found to be linear between 200ng/spot to 600ng/spot for Rosuvastatin calcium. The limit of detection and the limit of quantification for Rosuvastatin calcium were found to be 5.68ng/spot and 17.22ng/spot. The developed method was also validated . The method was found to be accurate, precise and reproducible and can be suitably applied for the determination of ROS in different dosage forms.
Rosuvastatin Calcium (ROS), HPTLC, Validation, Mobile Phase, Calibration curve.
V.V. Karkhanis, Vikas Parikh, Roma Panchal. Estimation of Rosuvastatin Calcium in Tablet Dosage Form by HPTLC Method. Asian J. Research Chem. 4(8): August; 2011; Page 1206-1209.
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