Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1340-1342

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Spectrophotometric Method for Determination of Pramipexole in Solid Dosage Forms



Address:   Mayur G. Raval*, Preeti Tiwari and C.N. Patel
Shree Sarvajanik Pharmacy Collage, Near Arvind Baug , Mehsana-384001, Gujarat, India.
*Corresponding Author
DOI No:

ABSTRACT:
The Objective Of the current study was to develop and validated UV spectrophotometric method for Pramipexole in solid dosage form. The method was validated by subjecting the drug to UV radiation. The drug was successfully quantified at 263 nm. The method was validated with respect to linearity, precision, accuracy, robustness. The response was linear over the range of 3-15 for Pramipexole. The recovery of the drugs from a mixture product was in the range of 99.00-101.46%. The utility of the procedure was verified by its application to marketed formulations. The specificity of the method was also checked with reference to placebo. The method was found to be specific also, hence other validation parameter were in the limit also.
KEYWORDS:
Pramipexole, Assay, UV Spectrophotometric, Validation, Mirapex.
Cite:
Mayur G. Raval, Preeti Tiwari, C.N. Patel. Development and Validation of Spectrophotometric Method for Determination of Pramipexole in Solid Dosage Forms. Asian J. Research Chem. 4(8): August, 2011; Page 1340-1342.
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