Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1210-1213

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development of RP- HPLC Method for Simultaneous Estimation of Amlodipine and Ramipril in Tablet Dosage form.



Address:   Maste M.M*., Kalekar M.C., Kadian N. and Bhat A.R.
Department of Pharmaceutical Chemistry, KLEU’s College of Pharmacy, Belgaum
*Corresponding Author
DOI No:

ABSTRACT:
Present work describes a precise, accurate and reproducible Reverse phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous estimation of Ramipril and Amlodipine in tablet dosage form on Phenomenex C18 column (245 mm × 4.5 mm, 5 µm, particle size) using acetonitrile: phosphate buffer, (60:40 v/v) as mobile phase at flow rate of 1.0 ml/min and the detection wavelength was 222 nm. The retention time for Ramipril and Amlodipine was found to be 3.41 and 6.10 min respectively. Proposed method was validated for precision, accuracy, linearity range, robustness and ruggedness.
KEYWORDS:
Amlodipine, Ramipril, RP-HPLC.
Cite:
Maste M.M., Kalekar M.C., Kadian N., Bhat A.R.. Development of RP- HPLC Method for Simultaneous Estimation of Amlodipine and Ramipril in Tablet Dosage form. Asian J. Research Chem. 4(8): August, 2011; Page 1210-1213.
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