Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  8

Year :  2011

Pages :   1235-1237

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous UV Spectrophotometric Method for Estimation of Fenofibrate and Metformine Hydrochloride in Tablet Dosage Form



Address:   Arpit Shah*, Dhanya B. Sen, Ashim Kumar Sen , Sharad Kumar, Aarti Zanwar and Jayesh Bodar.
Department of Pharmacy, Sumandeep Vidyapeeth , Pipariya, Vadodara (391760), Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, precise, reproducible and economical procedure for simultaneous estimation of Fenofibrate (FENO) and Metformin hydrochloride (MET) in tablet dosage form as well as in bulk drugs have been developed using double beam UV Spectrophotometer. The method based on solving of simultaneous equation using 239 nm (?max of FENO) and 218 nm (?max of MET) as two analytical wavelengths for both drugs. The method was found to be linear in the range of 1 – 6 mgml-1 and 3.125-18.75 mgml-1 with mean recovery of 99.6 % and 101.82 % of fenofibrate and metformine hydrochloride, respectively. The solution of both drugs was prepared using Methanol as a solvent. The proposed method is suitable for simultaneous determination of Fenofibrate and Metformin hydrochloride in pharmaceutical dosage form.
KEYWORDS:
, Metformine hydrochloride, Methanol, U.V, Simultaneous equation method.
Cite:
Arpit Shah, Dhanya B. Sen, Ashim Kumar Sen, Sharad Kumar, Aarti Zanwar, Jayesh Bodar. Simultaneous UV Spectrophotometric Method for Estimation of Fenofibrate and Metformine Hydrochloride in Tablet Dosage Form. Asian J. Research Chem. 4(8): August, 2011; Page 1235-1237.
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